DB1976
Product Specifications
CAS Number
1557397-51-9
Target
Apoptosis
Related Pathways
Apoptosis
Purity
0.9894
Bioactivity
DB1976 is a selenophene analog of DB270 and a highly potent, cell-permeable, fully efficacious transcription factor PU.1 inhibitor. It effectively inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. Additionally, DB1976 has an apoptosis-inducing effect.
Smiles
C(=N)(N)C=1C=C2NC(=NC2=CC1)C=3[Se]C(=CC3)C=4NC=5C(N4)=CC=C(C(=N)N)C5
Molecular Formula
C20H16N8Se
Molecular Weight
447.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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