CSRM617
Product Specifications
CAS Number
787504-88-5
Target
Apoptosis|||Androgen Receptor|||Others
Related Pathways
Endocrinology/Hormones|||Apoptosis|||Others
Bioactivity
CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor) . The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.
Smiles
C(=NNC(C(CO)N)=O)C1=C(O)C(O)=C(O)C=C1
Molecular Formula
C10H13N3O5
Molecular Weight
255.23
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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