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CSN5i-3

Product Specifications

CAS Number

2375740-98-8

Target

Apoptosis, Others

Related Pathways

Others, Apoptosis

Purity

>99.99%

Bioactivity

CSN5i-3 is a potent, selective, and orally available inhibitor of the proteolytic subunit of the CSN complex, CSN5. It inhibits CSN-catalyzed Cul1 deneddylation with an IC50 value of 5.8 nM. CSN5i-3 has a killing effect on a variety of cancer cells and can be used as an anticancer drug. [2]

Smiles

CC(C)n1nc(cc1C(=O)Nc1ccc([C@H]2[C@@H](O)CCCc3cncn23)c(c1)-c1ccccc1)C(F)F

Molecular Formula

C28H29F2N5O2

Molecular Weight

505.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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