Cot inhibitor-2
Product Specifications
CAS Number
915363-56-3
Target
MAPK, TNF
Related Pathways
Apoptosis, MAPK
Purity
0.9985
Bioactivity
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α production in human whole blood with an IC50 of 0.3 μM.
Smiles
CCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Molecular Formula
C26H25Cl2FN8
Molecular Weight
539.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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