Cot inhibitor-2
Product Specifications
CAS Number
915363-56-3
Target
MAPK, TNF
Related Pathways
Apoptosis, MAPK
Purity
0.9985
Bioactivity
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α production in human whole blood with an IC50 of 0.3 μM.
Smiles
CCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Molecular Formula
C26H25Cl2FN8
Molecular Weight
539.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
45936154 3x 1.0 µg DNA
SWAP70 CRISPR All-in-one AAV vector set (with saCas9)(Mouse)
Sign In for Pricing
View Details 
OR1065333-01 50 mg
4- (5-Chlorothiophen-2-yl) -3- (thiophen-2-yl) -2,5-dihydrofuran-2-one
Sign In for Pricing
View Details 
OR1065333-02 100 mg
4- (5-Chlorothiophen-2-yl) -3- (thiophen-2-yl) -2,5-dihydrofuran-2-one
Sign In for Pricing
View Details OR1065333-03 250 mg
4- (5-Chlorothiophen-2-yl) -3- (thiophen-2-yl) -2,5-dihydrofuran-2-one
Sign In for Pricing
View Details LV773004 1.0 µg DNA
POM121L7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)
Sign In for Pricing
View Details