COH34

Product Specifications

CAS Number

906439-72-3

Target

Others, Poly (ADP-ribose) Glycohydrolase (PARG)

Related Pathways

Cell Cycle/Checkpoint, Others

Purity

0.9957

Bioactivity

COH34 (1-[ (E) - (4-methylphenyl) sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.

Smiles

Cc1ccc(S\N=C\c2c(O)ccc3ccccc23)cc1

Molecular Formula

C18H15NOS

Molecular Weight

293.38

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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