COH34
Product Specifications
CAS Number
906439-72-3
Target
Others, Poly (ADP-ribose) Glycohydrolase (PARG)
Related Pathways
Cell Cycle/Checkpoint, Others
Purity
0.9957
Bioactivity
COH34 (1-[ (E) - (4-methylphenyl) sulfanyliminomethyl]naphthalen-2-ol) is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
Smiles
Cc1ccc(S\N=C\c2c(O)ccc3ccccc23)cc1
Molecular Formula
C18H15NOS
Molecular Weight
293.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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