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CNX-500

Product Specifications

CAS Number

1202758-21-1

Target

Others|||BTK

Related Pathways

Tyrosine Kinase/Adaptors|||Angiogenesis|||Others

Bioactivity

CNX-500, a probe comprising a covalent Btk inhibitor chemically linked to biotin, exhibits significant inhibitory activity against Btk (IC50: 0.5 nM) and can form a covalent bond with Btk. Additionally, CNX-500 has low inhibitory effects on kinase EGFR and upstream Src-family kinases.

Smiles

[H][C@]12CS[C@@H](CCCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCC(=O)NCCCOc3cccc(Nc4ncc(C)c(Nc5cccc(NC(=O)C=C)c5)n4)c3)[C@@]1([H])NC(=O)N2

Molecular Formula

C48H68N10O9S

Molecular Weight

961.18

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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