CHMFL-PI3KD-317
Product Specifications
CAS Number
2244992-76-3
Target
PI3K|||PI4K
Related Pathways
PI3K/Akt/mTOR signaling
Purity
0.9916
Bioactivity
CHMFL-PI3KD-317 is a highly potent, selective, and orally active PI3K? inhibitor with an IC50 of 6 nM, exhibiting over 10-1500 fold selectivity over other class I, II, and III PIKK family isoforms, such as PI3K? (IC50, 62.6 nM), PI3K? (IC50, 284 nM), PI3K? (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM), and PI4KIIIB (IC50, 300.2 nM) . It inhibits PI3K?-mediated Akt T308 phosphorylation in Raji cells with an EC50 of 4.3 nM and has antiproliferative effects on cancer cells.
Smiles
CC(C)[C@H](N)C(=O)Nc1nc(C)c(s1)-c1cnc(Cl)c(NS(=O)(=O)c2cccc(C)c2)c1
Molecular Formula
C21H24ClN5O3S2
Molecular Weight
494.03
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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