CHMFL-ABL/KIT-155
Product Specifications
CAS Number
2081093-21-0
Target
Bcr-Abl, c-Kit, PDGFR, Discoidin Domain Receptor (DDR), Apoptosis
Related Pathways
Apoptosis, Angiogenesis, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors
Bioactivity
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM) . It arrests cell cycle progression and induces apoptosis.
Smiles
C(C1=C(C(F)(F)F)C=C(C(NC2=CC(OC3CCN(C(=O)C=4C=CC(C)=NC4)CC3)=C(C)C=C2)=O)C=C1)N5CCN(C)CC5
Molecular Formula
C33H38F3N5O3
Molecular Weight
609.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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