WEE1-IN-4
WEE1-IN-4 (Compound 15) is a potent checkpoint Wee1 kinase inhibitor with an IC50 of 0.011 μM. Wee1 inhibitors can abrogate the G2/M checkpoint[1].
Product Specifications
CAS Number
622855-37-2
UNSPSC
12352005
Target
Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wee1-in-4.html
Concentration
10mM
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC(C2=C1C3=C(C=C2C4=CC=CC=C4Cl)NC5=C3C=C(O)C=C5)=O
Molecular Formula
C20H11ClN2O3
Molecular Weight
362.77
References & Citations
[1]Kanin Wichapong, et al. Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors. Eur J Med Chem. 2009 Apr;44 (4) :1383-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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