BPN-15606
Product Specifications
CAS Number
1914989-49-3
Target
Others, Gamma-secretase
Related Pathways
Proteases/Proteasome, Neuroscience, Others, Stem Cells
Bioactivity
BPN-15606, an orally active γ-secretase modulator (GSM), significantly reduces Aβ42 and Aβ40 production in SHSY5Y neuroblastoma cells, demonstrating IC50 values of 7 nM and 17 nM, respectively. This compound exhibits favorable pharmacokinetic/pharmacodynamic (PK/PD) properties, such as bioavailability, half-life, and clearance. Importantly, BPN-15606 markedly decreases Aβ42 and Aβ40 levels in the central nervous system of both rats and mice[1].
Smiles
COc1nc(ccc1-n1cnc(C)c1)-c1cc(C)c(N[C@@H](C)c2ccc(F)cc2)nn1
Molecular Formula
C23H23FN6O
Molecular Weight
418.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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