BMS-1001 hydrochloride
Product Specifications
CAS Number
2113650-04-5
Target
PD-1/PD-L1
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, Immunology/Inflammation
Purity
0.9957
Bioactivity
BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes.
Smiles
Cl.Cc1cc(CN[C@H](CO)C(O)=O)c(OCc2cccc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1
Molecular Formula
C35H35ClN2O7
Molecular Weight
631.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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