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BMS-1001 hydrochloride

Product Specifications

CAS Number

2113650-04-5

Target

PD-1/PD-L1

Related Pathways

Apoptosis, Cell Cycle/Checkpoint, Immunology/Inflammation

Purity

0.9957

Bioactivity

BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes.

Smiles

Cl.Cc1cc(CN[C@H](CO)C(O)=O)c(OCc2cccc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1

Molecular Formula

C35H35ClN2O7

Molecular Weight

631.11

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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