BJE6-106
Product Specifications
CAS Number
1564249-38-2
Target
PKC, Caspase, Apoptosis, JNK
Related Pathways
Chromatin/Epigenetic, Proteases/Proteasome, Apoptosis, Cytoskeletal Signaling, MAPK
Bioactivity
BJE6-106 (B106) is a selective PKCδ inhibitor (IC50 = 0.05 μM) with 1000-fold higher selectivity for PKCδ than PKCα (IC50 = 50 μM) . BJE6-106 induces caspase-dependent apoptosis, activates the JNK pathway and H2AX, and can be used to study NRAS-mutated melanoma.
Smiles
O=CC1=CC(=CC=2C=CC(OC12)(C)C)CCN3C=4C=CC=CC4C=5C=CC=CC53
Molecular Formula
C26H23NO2
Molecular Weight
381.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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