BI-4020
Product Specifications
CAS Number
2664214-60-0
Target
EGFR
Related Pathways
JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis
Purity
>99.99%
Bioactivity
BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. It exhibits activity against the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM), and EGFR wt (IC50=190 nM) . BI-4020 also shows high kinome selectivity and good DMPK properties.
Smiles
C[C@@H]1CCCOc2c(cnn2C)-c2cc(cc(C)n2)C(=O)\N=C2/Nc3ccc(CN4CCN(C)CC4)cc3N2C1
Molecular Formula
C30H38N8O2
Molecular Weight
542.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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