BI-4020
Product Specifications
CAS Number
2664214-60-0
Target
EGFR
Related Pathways
JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis
Purity
>99.99%
Bioactivity
BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. It exhibits activity against the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM), and EGFR wt (IC50=190 nM) . BI-4020 also shows high kinome selectivity and good DMPK properties.
Smiles
C[C@@H]1CCCOc2c(cnn2C)-c2cc(cc(C)n2)C(=O)\N=C2/Nc3ccc(CN4CCN(C)CC4)cc3N2C1
Molecular Formula
C30H38N8O2
Molecular Weight
542.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
M2750-12A-AP 100 µL
MCP2 (Macrophage/Monocyte Chemotactic Protein 2, Chemokine C-C Motif Ligand 8, CCL8, HC14, Monocyte Chemotactic Protein 2, Small Inducible Cytokine A8 Precursor, SCYA8, SCYA10) (AP) discontinued
Ask
View Details 