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BI-4020

Product Specifications

CAS Number

2664214-60-0

Target

EGFR

Related Pathways

JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis

Purity

>99.99%

Bioactivity

BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. It exhibits activity against the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM), and EGFR wt (IC50=190 nM) . BI-4020 also shows high kinome selectivity and good DMPK properties.

Smiles

C[C@@H]1CCCOc2c(cnn2C)-c2cc(cc(C)n2)C(=O)\N=C2/Nc3ccc(CN4CCN(C)CC4)cc3N2C1

Molecular Formula

C30H38N8O2

Molecular Weight

542.68

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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