PROTAC Bcl2 degrader-1

Product Specifications

CAS Number

2378801-85-3

Target

Bcl-2 Family|||PROTACs

Related Pathways

PROTAC|||Apoptosis

Bioactivity

PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 ?M) and Bcl-2 (IC50: 4.94 ?M; DC50: 3.0 ?M) .

Smiles

O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCOCCOCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=CC=CC=6C(SC7=CC=C(Br)C=C7)=CC=C(C4=O)C56)C3C2=O)CC1

Molecular Formula

C45H45BrN6O10S

Molecular Weight

941.84

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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