Lisaftoclax
Product Specifications
CAS Number
2180923-05-9
Target
Bcl-2 Family
Related Pathways
Apoptosis
Purity
0.9966
Bioactivity
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.
Smiles
[O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1
Molecular Formula
C45H48ClN7O8S
Molecular Weight
882.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15195909 1 Vial
Lentiviral mouse Nfkbie shRNA (UAS) - Lentiviral mouse Nfkbie shRNA (UAS, GFP) (100)
Sign In for Pricing
View Details B0496 96 Tests
28S ribosomal protein S30 mitochondrial (MRPS30) Bovine ELISA Kit
Sign In for Pricing
View Details 250544-Biotin 100 µL
PRRX1 (Paired Related Homeobox 1, PHOX1, PMX1, PRX1) (Biotin)
Sign In for Pricing
View Details MBS1305462-01 0.02 mg (E-Coli)
Recombinant Human Tetratricopeptide repeat protein 22 (TTC22)
Sign In for Pricing
View Details