Lisaftoclax
Product Specifications
CAS Number
2180923-05-9
Target
Bcl-2 Family
Related Pathways
Apoptosis
Purity
0.9966
Bioactivity
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.
Smiles
[O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1
Molecular Formula
C45H48ClN7O8S
Molecular Weight
882.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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