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Lisaftoclax

Product Specifications

CAS Number

2180923-05-9

Target

Bcl-2 Family

Related Pathways

Apoptosis

Purity

0.9966

Bioactivity

Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.

Smiles

[O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1

Molecular Formula

C45H48ClN7O8S

Molecular Weight

882.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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