Lisaftoclax
Product Specifications
CAS Number
2180923-05-9
Target
Bcl-2 Family
Related Pathways
Apoptosis
Purity
0.9966
Bioactivity
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.
Smiles
[O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1
Molecular Formula
C45H48ClN7O8S
Molecular Weight
882.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6240689-01 0.1 mL
SOCS3 (Suppressor of Cytokine Signaling 3, ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3) (MaxLight 750)
Sign In for Pricing
View Details MBS6240689-02 5x 0.1 mL
SOCS3 (Suppressor of Cytokine Signaling 3, ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3) (MaxLight 750)
Sign In for Pricing
View Details MBS6212619-01 0.1 mL
MCAT (MT, Malonyl-CoA-acyl Carrier Protein Transacylase, Mitochondrial, Mitochondrial Malonyl CoA:ACP Acyltransferase, Mitochondrial Malonyltransferase, [Acyl-carrier-protein] Malonyltransferase) (MaxLight 550)
Sign In for Pricing
View Details MBS6212619-02 5x 0.1 mL
MCAT (MT, Malonyl-CoA-acyl Carrier Protein Transacylase, Mitochondrial, Mitochondrial Malonyl CoA:ACP Acyltransferase, Mitochondrial Malonyltransferase, [Acyl-carrier-protein] Malonyltransferase) (MaxLight 550)
Sign In for Pricing
View Details K2644902 1.0 µg DNA
WTS sgRNA CRISPR Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 