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Aβ42-IN-1 free base

Product Specifications

CAS Number

2434633-17-5

Target

Others, Gamma-secretase

Related Pathways

Others, Proteases/Proteasome, Neuroscience, Stem Cells

Bioactivity

Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels with an IC50 of 0.091 μM, and significantly diminishes brain Aβ42 levels in mice. Given these properties, Aβ42-IN-1 free base represents a potential disease-modifying agent for Alzheimer's disease [1].

Smiles

CC1=C(N2C(=N1)C(OCC3=CC=C(C=C3)C4=CC=CC=C4)=CC=C2)C=5C=CC(C(NCC)=O)=NC5

Molecular Formula

C29H26N4O2

Molecular Weight

462.54

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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