Aβ42-IN-1 free base
Product Specifications
CAS Number
2434633-17-5
Target
Others|||Gamma-secretase
Related Pathways
Others|||Proteases/Proteasome|||Neuroscience|||Stem Cells
Bioactivity
A?42-IN-1 free base (compound 1v), an orally active ?-secretase modulator with high brain exposure, effectively lowers A?42 levels with an IC50 of 0.091 ?M, and significantly diminishes brain A?42 levels in mice. Given these properties, A?42-IN-1 free base represents a potential disease-modifying agent for Alzheimer's disease [1].
Smiles
CC1=C(N2C(=N1)C(OCC3=CC=C(C=C3)C4=CC=CC=C4)=CC=C2)C=5C=CC(C(NCC)=O)=NC5
Molecular Formula
C29H26N4O2
Molecular Weight
462.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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