AV-412
Product Specifications
CAS Number
451493-31-5
Target
EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Purity
0.9992
Bioactivity
AV-412 (MP412) is an EGFR inhibitor for EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M, and ErbB2, with IC50 values of 0.75, 0.79, 0.5, 2.3, and 19 nM, respectively.
Smiles
Cc1ccc(cc1)S(O)(=O)=O.Cc1ccc(cc1)S(O)(=O)=O.CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
Molecular Formula
C41H44ClFN6O7S2
Molecular Weight
851.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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