AV-412

Product Specifications

CAS Number

451493-31-5

Target

EGFR

Related Pathways

Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling

Purity

0.9992

Bioactivity

AV-412 (MP412) is an EGFR inhibitor for EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M, and ErbB2, with IC50 values of 0.75, 0.79, 0.5, 2.3, and 19 nM, respectively.

Smiles

Cc1ccc(cc1)S(O)(=O)=O.Cc1ccc(cc1)S(O)(=O)=O.CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

Molecular Formula

C41H44ClFN6O7S2

Molecular Weight

851.41

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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