AS2863619 free base
Product Specifications
CAS Number
2241300-50-3
Target
CDK|||STAT
Related Pathways
Stem Cells|||JAK/STAT signaling|||Cell Cycle/Checkpoint
Bioactivity
AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61 nM and 4.28 nM) . STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.
Smiles
Cc1nc2ccc(cc2[nH]1)-n1c(nc2cnccc12)-c1nonc1N
Molecular Formula
C16H12N8O
Molecular Weight
332.32
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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