AMG-548 dihydrochloride (864249-60-5 free base)
Product Specifications
Target
P38 MAPK
Related Pathways
MAPK
Bioactivity
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM) .
Smiles
O=C1N(C)C(NCC(N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4.Cl.Cl
Molecular Formula
C29H29Cl2N5O
Molecular Weight
534.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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