AMG-548
Product Specifications
CAS Number
864249-60-5
Target
Casein Kinase, p38 MAPK, Wnt/beta-catenin, TNF
Related Pathways
MAPK, Metabolism, Apoptosis, Stem Cells, Cytoskeletal Signaling
Purity
0.9991
Bioactivity
AMG-548 is a selective and orally active p38α MAPK inhibitor (Ki = 0.5 nM), with higher selectivity than p38β, p38γ, and p38δ, and can also inhibit the TNFα, CK1δ/ε, and Wnt signalling pathways.
Smiles
O=C1C(=C(N=C(NC[C@H](CC2=CC=CC=C2)N)N1C)C=3C=CN=CC3)C4=CC5=C(C=C4)C=CC=C5
Molecular Formula
C29H27N5O
Molecular Weight
461.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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