AMG-548

Product Specifications

CAS Number

864249-60-5

Target

Casein Kinase, p38 MAPK, Wnt/beta-catenin, TNF

Related Pathways

MAPK, Metabolism, Apoptosis, Stem Cells, Cytoskeletal Signaling

Purity

0.9991

Bioactivity

AMG-548 is a selective and orally active p38α MAPK inhibitor (Ki = 0.5 nM), with higher selectivity than p38β, p38γ, and p38δ, and can also inhibit the TNFα, CK1δ/ε, and Wnt signalling pathways.

Smiles

O=C1C(=C(N=C(NC[C@H](CC2=CC=CC=C2)N)N1C)C=3C=CN=CC3)C4=CC5=C(C=C4)C=CC=C5

Molecular Formula

C29H27N5O

Molecular Weight

461.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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