AMG-548

Product Specifications

CAS Number

864249-60-5

Target

Casein Kinase|||p38 MAPK|||Wnt/beta-catenin|||TNF

Related Pathways

MAPK|||Metabolism|||Apoptosis|||Stem Cells|||Cytoskeletal Signaling

Purity

0.9991

Bioactivity

AMG-548 is a selective and orally active p38? MAPK inhibitor (Ki = 0.5 nM), with higher selectivity than p38?, p38?, and p38?, and can also inhibit the TNF?, CK1?/?, and Wnt signalling pathways.

Smiles

O=C1C(=C(N=C(NC[C@H](CC2=CC=CC=C2)N)N1C)C=3C=CN=CC3)C4=CC5=C(C=C4)C=CC=C5

Molecular Formula

C29H27N5O

Molecular Weight

461.56

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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