AMG 487
Product Specifications
CAS Number
473719-41-4
Target
CXCR
Related Pathways
GPCR/G Protein, Autophagy, Immunology/Inflammation
Purity
0.9989
Bioactivity
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
Smiles
CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1
Molecular Formula
C32H28F3N5O4
Molecular Weight
603.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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