AMG 487

Product Specifications

CAS Number

473719-41-4

Target

CXCR

Related Pathways

GPCR/G Protein|||Autophagy|||Immunology/Inflammation

Purity

0.9989

Bioactivity

AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.

Smiles

CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1

Molecular Formula

C32H28F3N5O4

Molecular Weight

603.59

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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