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AKT-IN-3

Product Specifications

CAS Number

2374740-21-1

Target

Apoptosis, Akt

Related Pathways

PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Apoptosis

Bioactivity

AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3) . AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK.

Smiles

CNC(=O)C[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(F)c(F)c1

Molecular Formula

C23H23Cl2F2N5O3

Molecular Weight

526.36

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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