AKT-IN-3
Product Specifications
CAS Number
2374740-21-1
Target
Apoptosis|||Akt
Related Pathways
PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling|||Apoptosis
Bioactivity
AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3) . AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK.
Smiles
CNC(=O)C[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(F)c(F)c1
Molecular Formula
C23H23Cl2F2N5O3
Molecular Weight
526.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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