ACP-5862
Product Specifications
CAS Number
2230757-47-6
Target
BTK|||Drug Metabolite|||Cytochromes P450
Related Pathways
Tyrosine Kinase/Adaptors|||Metabolism|||Angiogenesis
Bioactivity
ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for BTK) . Acalabrutinib is an irreversible and highly selective BTK inhibitor (IC50: 3 nM; EC50: 8 nM) .
Smiles
CC#CC(=O)NCCCC(=O)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12
Molecular Formula
C26H23N7O3
Molecular Weight
481.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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