ACP-5862

Product Specifications

CAS Number

2230757-47-6

Target

BTK|||Drug Metabolite|||Cytochromes P450

Related Pathways

Tyrosine Kinase/Adaptors|||Metabolism|||Angiogenesis

Bioactivity

ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for BTK) . Acalabrutinib is an irreversible and highly selective BTK inhibitor (IC50: 3 nM; EC50: 8 nM) .

Smiles

CC#CC(=O)NCCCC(=O)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12

Molecular Formula

C26H23N7O3

Molecular Weight

481.51

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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