AAPK-25
Product Specifications
CAS Number
2247919-28-2
Target
Apoptosis, Aurora Kinase, PLK
Related Pathways
Cell Cycle/Checkpoint, Chromatin/Epigenetic, Apoptosis
Purity
0.9779
Bioactivity
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, causing mitotic delay and arresting cells in prometaphase, followed by increased apoptosis. It targets Aurora-A/-B/-C with Kd values ranging from 23-289 nM.
Smiles
Clc1ccc(cc1Cl)C(=O)Nc1ccc2cc(ccc2c1)C(=O)Nc1nccs1
Molecular Formula
C21H13Cl2N3O2S
Molecular Weight
442.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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