A 1070722
Product Specifications
CAS Number
1384424-80-9
Target
GSK-3
Related Pathways
PI3K/Akt/mTOR signaling, Stem Cells
Purity
0.999
Bioactivity
A 1070722 is a potent and selective GSK-3 inhibitor, exhibiting high affinity for both GSK-3α (Ki = 0.6 nM) and GSK-3β (Ki = 0.6 nM) . It can penetrate the blood-brain barrier (BBB) and accumulate in brain regions, indicating potential use as a PET radiotracer for quantifying GSK-3 in the brain.
Smiles
COc1ccc2c(NC(=O)Nc3cccc(n3)C(F)(F)F)ccnc2c1
Molecular Formula
C17H13F3N4O2
Molecular Weight
362.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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