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A 1070722

Product Specifications

CAS Number

1384424-80-9

Target

GSK-3

Related Pathways

PI3K/Akt/mTOR signaling|||Stem Cells

Purity

0.999

Bioactivity

A 1070722 is a potent and selective GSK-3 inhibitor, exhibiting high affinity for both GSK-3? (Ki = 0.6 nM) and GSK-3? (Ki = 0.6 nM) . It can penetrate the blood-brain barrier (BBB) and accumulate in brain regions, indicating potential use as a PET radiotracer for quantifying GSK-3 in the brain.

Smiles

COc1ccc2c(NC(=O)Nc3cccc(n3)C(F)(F)F)ccnc2c1

Molecular Formula

C17H13F3N4O2

Molecular Weight

362.31

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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