5-Iodo-indirubin-3'-monoxime
Product Specifications
CAS Number
331467-03-9
Target
CDK|||GSK-3
Related Pathways
PI3K/Akt/mTOR signaling|||Stem Cells|||Cell Cycle/Checkpoint
Bioactivity
5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3?, CDK5/P25, and CDK1/cyclin B, competing with ATP for binding to the catalytic site of the kinase (IC50s: 9, 20, and 25 nM) .
Smiles
O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(I)cc12
Molecular Formula
C16H10IN3O2
Molecular Weight
403.17
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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