2',3'-cGAMP
Product Specifications
CAS Number
1441190-66-4
Target
Immunology/Inflammation related, COX, cGAS, STING, Endogenous Metabolite, IFNAR
Related Pathways
Metabolism, Neuroscience, Immunology/Inflammation
Purity
0.9865
Bioactivity
2',3'-cGAMP is an endogenous cyclic dinucleotide (CDN) produced by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. It acts as a STING activator and ligand, inducing interferons (IFNs) via the TBK1/IRF3 pathway and pro-inflammatory factors via the NF-κB pathway.
Smiles
O[C@H]1[C@@]2([C@@H](O[C@]1(COP(=O)(O)O[C@@]3([C@@](COP(=O)(O)O2)(O[C@H]([C@@H]3O)N4C=5C(N=C4)=C(N)N=CN5)[H])[H])[H])N6C7=C(N=C6)C(=O)N=C(N)N7)[H]
Molecular Formula
C20H24N10O13P2
Molecular Weight
674.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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