HG6-64-1

HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1) ; has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells.

Product Specifications

CAS Number

[1315329-43-1]

Product Name Alternative

HMSL 10017-101-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HG6-64-1.html

Purity

99.69

Solubility

DMSO : 75 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(/C=C/C4=CN=C(NC=C5)C5=C4OC)=C3

Molecular Formula

C32H34F3N5O2

Molecular Weight

577.64

Precautions

H302, H315, H319, H335

References & Citations

[1]WO 2011090738 A2

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

B-Raf

Available Sizes

Curated Selection

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