HG6-64-1
HG6-64-1 is a potent and selective B-Raf inhibitor extracted from patent WO 2011090738 A2, example 9 (XI-1) ; has a IC50 of 0.09 μM on B-raf V600E transformed Ba/F3 cells.
Product Specifications
CAS Number
[1315329-43-1]
Product Name Alternative
HMSL 10017-101-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HG6-64-1.html
Purity
99.69
Solubility
DMSO : 75 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(/C=C/C4=CN=C(NC=C5)C5=C4OC)=C3
Molecular Formula
C32H34F3N5O2
Molecular Weight
577.64
Precautions
H302, H315, H319, H335
References & Citations
[1]WO 2011090738 A2
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Available Sizes
Curated Selection
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