GK187

GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI (50) value of 0.0001. GK187 can be used for researching various neurological disorders[1]. [The XI (50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]

Product Specifications

CAS Number

[1071001-50-7]

UNSPSC

12352005

Hazard Statement

H225-H302-H319-H336

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gk187.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCCCC1=CC=C(OC)C=C1)C(F)(F)C(F)(F)F

Molecular Formula

C14H15F5O2

Molecular Weight

310.26

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P330-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Magrioti V, et al. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorg Med Chem. 2013 Sep 15;21 (18) :5823-9.