What is the catalog number for Tofacitinib?

The catalog number for Tofacitinib is HY-40354.

What sizes are available for Tofacitinib?

Tofacitinib is available in the following size(s): 5 mg, 10 mg, 10 mM - 1 mL, 50 mg, 100 mg, 200 mg, 500 mg, 1 g.

How many pack sizes does Tofacitinib come in?

Tofacitinib is available in 8 different pack sizes.

Is Tofacitinib in stock?

Tofacitinib is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Tofacitinib?

Tofacitinib is manufactured by QuantiMol.

What is the estimated delivery time for Tofacitinib?

Estimated delivery time for Tofacitinib is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Tofacitinib?

The safety data sheet for Tofacitinib is available here: http://file.medchemexpress.com/batch_PDF/HY-40354/Tofacitinib-SDS-MedChemExpress.pdf.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Tofacitinib

Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.

Product Specifications

CAS Number

477600-75-2

Product Name Alternative

Tasocitinib; CP-690550

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; JAK

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Tofacitinib.html

Purity

99.99

Solubility

DMSO : 125 mg/mL (ultrasonic) |Ethanol : 2.5 mg/mL (ultrasonic)

Smiles

O=C(CC#N)N1C[C@H](N(C2=C3C(NC=C3)=NC=N2)C)[C@H](C)CC1

Molecular Formula

C16H20N6O

Molecular Weight

312.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Jiang JK, et al. Examining the chirality, conformation and selective kinase inhibition of 3- ((3R,4R) -4-methyl-3- (methyl (7H-pyrrolo[2,3-d]pyrimidin-4-yl) amino) piperidin-1-yl) -3-oxopropanenitrile (CP-690,550) . J Med Chem. 2008 Dec 25;51 (24) :8012-8.|[2]Onda M, et al. Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts. J Immunol. 2014 Jul 1;193 (1) :48-55.|[3]LaBranche TP, et al. JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production. Arthritis Rheum. 2012 Nov;64 (11) :3531-42.|[4]Calama E, et al. Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS. Pulm Pharmacol Ther. 2017 Apr;43:60-67.