Velnacrine
Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an IC50 of 3.27 μM. Velnacrine reverses the Scopolamine -induced amnesia in rat models, and exhibits acute toxicity with LD50 of 65 mg/kg[1].
Product Specifications
CAS Number
124027-47-0
Product Name Alternative
HP 029 (free base) ; Hydroxytacrine
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/velnacrine.html
Purity
98.60
Smiles
OC1CCCC2=NC3=CC=CC=C3C(N)=C21
Molecular Formula
C13H14N2O
Molecular Weight
214.26
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Tabarrini O, et al., Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease. Bioorg Med Chem. 2001 Nov;9 (11) :2921-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
AChE
Available Sizes
Frequently Asked Questions
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