NKY80

NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues[1][2].

Product Specifications

CAS Number

[299442-43-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Adenylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nky80.html

Purity

99.76

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1C2=CN=C(N)N=C2CC(C3=CC=CO3)C1

Molecular Formula

C12H11N3O2

Molecular Weight

229.24

Precautions

H302

References & Citations

[1]Onda T, et al. Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibitionof adenylyl cyclase isoforms. Biol Chem. 2001 Dec 21;276 (51) :47785-93.|[2]Harney JA, et al. Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP. Am J Physiol Endocrinol Metab. 2008 Jul;295 (1) :E155-61.|[3]Ortiz-Capisano MC, et al. Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells. Hypertension. 2007 Mar;49 (3) :618-24.