IRAK4-IN-14
IRAK4-IN-14 (compound 28) is a potent, selective and orally active IRAK4 inhibitor with an IC50 of 0.003 μM. IRAK4-IN-14 shows good PK parameters in rats and mouse. IRAK4-IN-14 shows synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib[1].
Product Specifications
CAS Number
2667681-71-0
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/irak4-in-14.html
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=NC=C(C2=NC3=C(OC4(C)CC4)N=C(NC5=CN(C6CCN(C)CC6)N=C5)N=C3C=C2F)C=N1
Molecular Formula
C25H28FN9O
Molecular Weight
489.55
References & Citations
[1]Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28 (23) :115815.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP762748 50 µg
p57 Kip2 (CDKN1C) (NM_000076) Human Recombinant Protein
Sign In for Pricing
View Details 
E-EL-M2453-01 24 Tests
Mouse IL-6R (Interleukin 6 Receptor) ELISA Kit
Sign In for Pricing
View Details